Is there a relationship between ACTN3 R577X gene polymorphism and sarcopenia?
| Autor: | Gülistan Bahat-Öztürk, Banu Ozulu Turkmen, Aynur Daglar, Mustafa Kahraman, Sukru Ozturk, Mehmet Akif Karan, Meryem Merve Oren, Ali Sarper Diler, Ayla Sahin, Nezahat Muge Catikkas, Sukru Palanduz |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Percentile Sarcopenia Multivariate analysis Genotype Polymorphism (computer science) Internal medicine medicine Outpatient clinic Humans Actinin Aged Aged 80 and over Polymorphism Genetic Hand Strength business.industry Mean age medicine.disease Cross-Sectional Studies Female Gene polymorphism Geriatrics and Gerontology business Body mass index |
| Zdroj: | Aging clinical and experimental research. 34(4) |
| ISSN: | 1720-8319 |
| Popis: | The alpha-actinin (ACTN) genes are important structural components of the sarcomere. Sarcopenia is a common geriatric syndrome characterized by morbidity and mortality. Our study aimed to examine the relationship between the ACTN3 R577X gene and sarcopenia in community-dwelling Turkish adults. We designed a cross-sectional study among the patients aged ≥ 65 years admitted to the geriatric outpatient clinic. We recorded the general characteristics of the patients. We used the Jamar hand dynamometer to evaluate handgrip strength. Body composition was estimated using bioimpedance analysis. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People2 criteria with population-specific cutoffs. We performed analyses of low muscle mass (LMM) with skeletal muscle mass index adjusted for body mass index [SMMI(BMI)]. We further categorized the SMMI(BMI) cutoffs into tenths. The analyzes were performed according to the 90th percentile SMMI(BMI) cutoffs. Peripheral blood samples were collected to determine the ACTN3 genotypes. 197 participants were included [mean age: 76.3 ± 6.1 years, 151 (76.6%) women]. The proportions of the ACTN3 genotypes were as follows: RX (45.1%) > RR (31%) > XX (23.9%). The significant difference between genotypes was found only for low SMMI(BMI) according to the 90th percentile (p = 0.025). In multivariate analysis, only gender (female) was independently associated with LMM. We did not find any association between ACTN3 R577X gene polymorphism and probable sarcopenia, confirmed sarcopenia and LMM. Besides, much more research is needed to reveal how ethnicity affects the muscles of older adults with ACTN3 R577X gene polymorphism. |
| Databáze: | OpenAIRE |
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