Slowing of information processing speed without motor slowing in multiple sclerosis observed during two crossing-off tasks

Autor: M. Binetruy, Pierre Vandel, Eric Laurent, Eloi Magnin, Gilles Chopard, Thibault Moreau, Jean Galmiche
Přispěvatelé: Centre de soins Les Tilleroyes [Besançon], Regional Network for Diagnosis Aid and Management of patients with Cognitive Impairment in the Franche-Comté geographical area, Centre Mémoire de Ressources et de Recherche [CHRU de Besançon] (CMRR), Hôpital Saint-Jacques [CHRU de Besançon] -Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire de Psychologie - UFC (EA 3188) (PSYCHO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Mémoire de Ressources et de Recherche [Besançon] ( CMRR ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Département de psychiatrie [CHU de Besançon], Laboratoire de Psychologie - UFC ( PSYCHO ), Université de Franche-Comté ( UFC ), Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon )
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Revue Neurologique
Revue Neurologique, Elsevier Masson, 2016, 172 (3), pp.225-230. ⟨10.1016/j.neurol.2015.12.008⟩
Revue Neurologique, Elsevier Masson, 2016, 172 (3), pp.225-230. 〈http://www.em-consulte.com/article/1045576/alertePM〉. 〈10.1016/j.neurol.2015.12.008〉
ISSN: 0035-3787
DOI: 10.1016/j.neurol.2015.12.008⟩
Popis: Introduction Slowing of information processing speed (IPS) is often considered one of the primary deficits seen in multiple sclerosis (MS). IPS is usually measured by tasks that involve many cognitive functions. The aim of this study was to determine whether similar IPS slowing can also be observed during two simple, timed, psychomotor crossing-off tasks. Method The Crossing-Off Test (COT), a simple psychomotor task, was performed under two conditions (COT1 corresponded to writing habits, COT2 used horizontal sweeping) in 25 relapsing–remitting MS patients (EDSS 0–1) and 25 healthy controls. Results The MS group compared with the control group was impaired on COT1 (P = 0.0043) and not on COT2 (P = 0.4), and the COT1 performance of MS patients with EDSS 1 was more impaired than those of patients with EDSS 0 (P = 0.008). Discussion/conclusion These results indicate that only some of the IPS cognitive subcomponents linked with COT1 tasks are initially involved in the slowing of IPS during MS, suggesting that different mechanisms are involved in each tested version of the COT.
Databáze: OpenAIRE
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