Anticonvulsant Effects of Aerial Parts of Verbena officinalis Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors
| Autor: | Seyed Mahdi Rezayat, Ahmad Reza Dehpour, Fatemeh Kazemi, S. E. Mehr, Amir Rashidian, Saeed Mehrzadi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.drug_class medicine.medical_treatment Phytochemicals (+)-Naloxone Pharmacology Mice 03 medical and health sciences 0302 clinical medicine Convulsion medicine Animals Receptor Benzodiazepine biology pentylenetetrazole Naloxone Plant Extracts business.industry Receptors Opioid kappa Verbena officinalis Verbena Original Articles traditional Persian medicine Plant Components Aerial Receptors GABA-A biology.organism_classification 030104 developmental biology Anticonvulsant Opioid Anesthesia Anticonvulsants medicine.symptom anticonvulsant business maximal electroshock 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Evidence-based Complementary & Alternative Medicine |
| ISSN: | 2156-5899 2156-5872 |
| DOI: | 10.1177/2156587217709930 |
| Popis: | To evaluate the anticonvulsant activity of the aerial parts of Verbena officinalis used traditionally by local Iranians for the treatment of convulsion. The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizures in mice. Diazepam was used as reference drug. In addition, for investigating the mechanism of V officinalis in PTZ model, flumazenil and naloxone were injected before V officinalis. The extract showed no toxicity and significantly increased the period taken before the onset and decreased the duration of the seizures induced by PTZ. In the MES test, V officinalis displayed significant reduction in hind limb tonic extension duration in a dose-dependent manner. The results propose that V officinalis ethanolic extract has anticonvulsant activity against seizure. It seems that these effects may be related to potentiating of GABAergic system. Moreover, this study supports the use of this plant by local Iranians in order to treat convulsion. |
| Databáze: | OpenAIRE |
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