Predictors of gastroduodenal erosions in patients taking low-dose aspirin

Autor:	Neville D. Yeomans, Nicholas J. Talley, A. B. R. Thomson, Christopher J. Hawkey, Angel Lanas, Jorgen Naesdal, John Hart
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Analgesic Gastroenterology Helicobacter Infections Risk Factors Internal medicine medicine Humans Pharmacology (medical) Stomach Ulcer Antipyretic Adverse effect Aspirin Dose-Response Relationship Drug Helicobacter pylori Hepatology biology medicine.diagnostic_test business.industry Stomach Anti-Inflammatory Agents Non-Steroidal Endoscopy Middle Aged biology.organism_classification Immunohistochemistry Surgery medicine.anatomical_structure Gastric Mucosa Duodenum Female business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 31:143-149
ISSN:	1365-2036 0269-2813
Popis:	Summary Background Gastroduodenal ulcers are common in patients taking low-dose aspirin. However, the factors predisposing to mucosal erosions, the precursor lesions, are not well known. Aims To examine the potential risk factors for the development of erosions in patients chronically taking low-dose aspirin. Methods Patients included were taking aspirin 75–325 mg daily for >28 days. Exclusion criteria included use of nonsteroidal anti-inflammatory and ulcer-healing drugs. Demographic data were collected at baseline, prior to endoscopy to determine the frequency and number of erosions and Helicobacter pylori status. In those without ulcer or other exclusions, endoscopy was repeated at 3 months. Results Fewer patients had gastric erosions if they were H. pylori +ve (48.5% vs. 66.4% in H. pylori−ve patients at baseline, P = 0.17; 40.0% vs. 64.1% at 3 months, P = 0.029). If gastric erosions were present, they were also less numerous in H. pylori +ve patients (3.61 ± 0.83 vs. 4.90 ± 0.53 at baseline, P = 0.026; 2.17 ± 0.68 vs. 5.68 ± 0.86 at 3 months, P = 0.029). There was a trend (0.1 > P > 0.05) for more gastric erosions in those taking >100 mg/day aspirin. Males had more duodenal erosions at baseline (25.2% vs. 7.5%, P = 0.016). Patient age did not affect the presence or number of erosions. H. Pylori was not significantly associated with duodenal erosion numbers. Conclusions Helicobacter pylori infection may partially protect against low-dose aspirin-induced gastric erosions; damage to the stomach appears weakly dose-related; and older age does not increase the risk of erosions.
Databáze:	OpenAIRE
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