Ten-Day Sequential Therapy of Helicobacter pylori Infection in Thailand
| Autor: | Somying Tumwasorn, Varocha Mahachai, Nathavut Sirimontaporn, Duangporn Thong-Ngam |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors genetic structures Antibiotics Severity of Illness Index Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Cohort Studies Clarithromycin Prospective Studies Middle Aged Thailand Anti-Bacterial Agents Treatment Outcome Breath Tests Drug Therapy Combination Female medicine.drug Adult medicine.medical_specialty medicine.drug_class Lansoprazole Microbial Sensitivity Tests Risk Assessment Drug Administration Schedule Helicobacter Infections Macrolide Antibiotics Microbiology Young Adult Antibiotic resistance Metronidazole Internal medicine Gastroscopy medicine Humans Aged Probability Dose-Response Relationship Drug Helicobacter pylori Hepatology business.industry Amoxicillin digestive system diseases Regimen Patient Compliance business Follow-Up Studies |
| Zdroj: | American Journal of Gastroenterology. 105:1071-1075 |
| ISSN: | 0002-9270 |
| Popis: | Antimicrobial resistance has decreased eradication rates of Helicobacter pylori worldwide. The objective of this study was to determine whether a sequential therapy regimen is effective in eradicating H. pylori in adults with nonulcer dyspepsia or peptic ulcer disease in Thailand.A total of 115 patients with dyspepsia or peptic ulcer were enrolled in the study. (14)C-urea breath test, upper endoscopy, rapid urease test, bacterial culture, and antibiotic resistance assessment were conducted during the course of the treatment. In all, 115 patients underwent a 10-day sequential regimen, which consisted of lansoprazole (30 mg) plus amoxicillin (1 g) twice a day for 5 days, then lansoprazole (30 mg) with metronidazole (500 mg) twice a day, and clarithromycin (1,000 mg) once a day for another 5 consecutive days. Successful eradication was evaluated by negative urea breath test at least 4 weeks after stopping treatment.Successful eradication was achieved in 106 of 115 patients (95%). All patients completed the treatment, without any dropouts. Mild adverse effects included headache and palpitations. The prevalence rate of clarithromycin-resistant H. pylori was found to be 6.1%.The 10-day sequential treatment for H. pylori is well tolerated and provides a high eradication rate. This regimen can overcome the emergence of antibiotic resistance and may have a role as a first-line treatment for H. pylori infection in Thailand. |
| Databáze: | OpenAIRE |
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