Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)
| Autor: | Lionel Sebbag, Lisa K. Uhl, David J. Maggs, Hiroko Iwashita, Jonathan P. Mochel, Akihiko Saito |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Response to therapy genetic structures 040301 veterinary sciences Aqueous tear deficiency Dry eye Cat Diseases 030308 mycology & parasitology Keratitis 0403 veterinary science 03 medical and health sciences Reference Values Ophthalmology medicine KERATOCONJUNCTIVITIS SICCA Animals Veterinary Sciences Small Animals Physical Examination tear film Retrospective Studies 0303 health sciences CATS business.industry Diagnostic test lacrimal 04 agricultural and veterinary sciences medicine.disease Conjunctivitis eye diseases keratitis Tears Cats Dry Eye Syndromes Female sense organs business keratoconjunctivitis sicca |
| Zdroj: | Journal of feline medicine and surgery, vol 21, iss 10 Uhl, LK; Saito, A; Iwashita, H; Maggs, DJ; Mochel, JP; & Sebbag, L. (2018). Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes).. Journal of feline medicine and surgery, 1098612X18810867. doi: 10.1177/1098612x18810867. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8dp6r1x1 |
| DOI: | 10.1177/1098612x18810867. |
| Popis: | Objectives The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval. Methods The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values Results Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease was bilateral in 5/10 cats. Clinical signs included conjunctivitis (14/17 eyes), corneal ulceration (6/17 eyes), non-ulcerative keratitis (4/17 eyes), symblepharon (4/17 eyes), eosinophilic keratitis (3/17 eyes), corneal sequestrum (3/17 eyes), corneal fibrosis (2/17 eyes) and meibomitis (2/17 eyes). Management included: topically applied lacrimomimetics, antiviral drugs, corticosteroids or immunomodulatory drugs; orally administered famciclovir; or surgical procedures, in various combinations. Response to therapy (defined as an increase in STT-1 value of ⩾5 mm/min) was transient (seen at a single reassessment) in 65% of eyes and sustained (seen at ⩾2 consecutive reassessments) in 18% of eyes. Conclusions and relevance Clinical features seen in cats with low STT-1 values are described, although the association between aqueous deficiency and the reported ocular changes is unknown at this time. We encourage clinicians to assess the tear film in cats with ocular surface disease, and initiate therapy with lacrimomimetics if STT-1 values are repeatedly below normal. Such information will further define aqueous tear deficiency in cats, providing a better understanding of disease prevalence, pathogenesis and treatment. |
| Databáze: | OpenAIRE |
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