Silver nanoparticles influenced rat serum metabolites and tissue morphology
| Autor: | Oluyomi Stephen Adeyemi, Ifeoluwa Adewumi, Temiloluwa Oluwashindara Faniyan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cellular pathology Silver Physiology Administration Oral Pharmacology Kidney Silver nanoparticle Random Allocation chemistry.chemical_compound Oral administration Drug Discovery medicine Animals Urea Rats Wistar Creatinine Dose-Response Relationship Drug Chemistry General Medicine Rats Dose–response relationship medicine.anatomical_structure Liver Toxicity Nanoparticles |
| Zdroj: | Journal of Basic and Clinical Physiology and Pharmacology. 26 |
| ISSN: | 2191-0286 0792-6855 |
| DOI: | 10.1515/jbcpp-2013-0092 |
| Popis: | Silver nanoparticles (AgNPs) are increasingly and extensively being applied for biomedical purposes. However, studies on the safety/toxicity profiles of AgNPs are limited. This necessitates the further studies in this direction. Here, we studied the effect of AgNP administration on rat serum metabolites and tissue morphology.: Rats were randomly distributed into eight groups of five animals each. Oral administration of AgNPs to rats at 100, 1000, and 5000 mg/kg was done daily and carried out for 7, 14, and 21 days alternately. The control received distilled water. Animals were sacrificed under diethyl ether anesthesia 24 h after cessation of last treatments. The blood and vital organs were harvested and prepared for biochemical and histopathology examinations, respectively.: Data revealed that AgNP administration at the different dosages caused elevated serum urea and creatinine levels. On the other hand, levels of inorganic phosphate in rat serum following administration of AgNPs were significantly (p: We show evidence suggesting that AgNPs may have potential to adversely affect the kidney functions as well as capability to cause myriad of cellular damage. |
| Databáze: | OpenAIRE |
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