SARS-CoV-2 antibody seroprevalence follow-up in Malagasy blood donors during the 2020 COVID-19 Epidemic
| Autor: | Zely Arivelo Randriamanantany, Paquerette Hanitriniala Sahondranirina, Matthieu Schoenhals, Manuela Christophère Vololoniaina, Niry Rabenindrina, Soa Fy Andriamandimby, Jean-Michel Heraud, Voahangy Rasolofo, Philippe Dussart, Fidiniana Mamy Randriatsarafara, Rindra Randremanana, Jean Marius Rakotondramanga, André Spiegel |
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| Přispěvatelé: | Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Ministère de la Santé Publique [Antananarivo, Madagascar], This project was funded by the United States Agency for International Development. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Medicine (General) Blood transfusion medicine.medical_treatment Antibodies Viral Blood donors General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine R5-920 Seroepidemiologic Studies Epidemiology medicine Madagascar Seroprevalence Humans Cumulative incidence Seroconversion Epidemics biology business.industry SARS-CoV-2 Incidence (epidemiology) Incidence COVID-19 General Medicine 3. Good health 030104 developmental biology SARS-CoV-2 Seroprevalence 030220 oncology & carcinogenesis Population Surveillance biology.protein Medicine [SDV.IMM]Life Sciences [q-bio]/Immunology Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Antibody business Demography |
| Zdroj: | EBioMedicine EBioMedicine, Elsevier, 2021, 68, pp.103419. ⟨10.1016/j.ebiom.2021.103419⟩ EBioMedicine, Vol 68, Iss, Pp 103419-(2021) |
| ISSN: | 2352-3964 |
| Popis: | We thank the blood donors and RBTC staff who supported this work, importantly Drs Jocelyne Nirina ANDRIAMBELO (RBTC Toamasina), Léa Isabelle RAMANDIMBISOA (RBTC Toliara), Michael Marie Osé HARIOLY NIRINA (NRTC Antananarivo), Dr Danielle FITAHIANA (RBTC Fianarantsoa) and Pr Tahiry RABENANDRIANINA (RBTC Mahajanga).We thank the Immunology of Infectious Diseases unit staff for performing assays, as well as the 4 laboratories in Madagascar where RT-PCRs were run particularly the IPM virology unit.We express our gratitude to the National Institute of Statistics of Madagascar and its Director General Isaora Zefania ROMALAHY, for sharing with us the 2020 demographics of Madagascar; International audience; Background: The incidence of the 2020 COVID-19 epidemic in Africa seems to be different from that of the rest of the world, however its true extent is probably underestimated. Conducting population based sero-surveys during the epidemic has moreover been extremely challenging, driving our group and others to study blood donor samples.Methods: We collected regional epidemiological COVID-19 surveillance data, and simultaneously monitored anti-SARS-CoV-2 antibody seroprevalences monthly throughout the epidemic in 5 major Region-associated Blood Transfusion Centres of Madagascar over a period of 9 months.Findings: Soon after attaining the first epidemic peaks between May and August 2020, both crude and population-weighted test-performance-adjusted seroprevalences of anti-SARS-CoV-2 antibodies was in Malagasy blood donors rapidly increased up to over 40% positivity.Interpretation: These findings suggest a high cumulative incidence of infection and seroconversion, which may have contributed to the observed deceleration of infection rates, but was not sufficient to prevent the second epidemic wave that struck Madagascar in Spring 2021. |
| Databáze: | OpenAIRE |
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