Corneal mineralization in wistar hannover rats
| Autor: | Yumi Wako, Satomi Hashimoto, Sou Wada, Minoru Tsuchitani, Takuya Doi, Junko Sato |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Mineralization (geology) Mineralization business.industry Background data chemistry.chemical_element Calcium Keratocyte Toxicology Pathology and Forensic Medicine Cornea medicine.anatomical_structure chemistry Wistar Hannover rat Medicine Original Article business Von Kossa stain Histological examination |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 0914-9198 |
| Popis: | We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been fre- quently observing corneal mineralization in Wistar Hannover rats of both the RccHan TM :WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The inci- dence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa's method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance. (DOI: 10.1293/tox.26.275; J Toxicol Pathol 2013; 26: 275-281) |
| Databáze: | OpenAIRE |
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