Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma

Autor:	Jianye Yuan, Zelin Weng, Zihui Tan, Kongjia Luo, Jian Zhong, Xiuying Xie, Chunhua Qu, Xiaodan Lin, Hong Yang, Jing Wen, Jianhua Fu
Rok vydání:	2022
Předmět:	Cancer Research Oncology Esophageal Neoplasms Carcinoma Squamous Cell Humans Esophageal Squamous Cell Carcinoma Chemoradiotherapy Neoadjuvant Therapy
Zdroj:	Cancer letters. 553
ISSN:	1872-7980
Popis:	Neoadjuvant chemoradiotherapy (NCRT) followed by surgery is recommended for locally advanced esophageal squamous cell carcinoma (ESCC) treatment. Patients who achieve a pathological complete response (pCR) have better survival. Our study aimed to discover immune-associated predictors of pCR in ESCC. Herein, we found that Th1-cell infiltration inferred from RNA sequencing was higher in the pCR group than in the non-pCR group. Multiplexed immunohistochemistry (mIHC) confirmed that Th1-, CD8
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65529e24a74f0fc4f75d25d5298b9641 https://pubmed.ncbi.nlm.nih.gov/36279981 Zobrazit plný text záznamu Full Text from ScienceDirect