Ampicillin plus ciprofloxacin therapy of experimental endocarditis caused by multidrug-resistant Enterococcus faecium
| Autor: | John M. Quale, Neville Mobarakai, David Landman, Mohammad M. Zaman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Enterococcus faecium Antibiotics Microbial Sensitivity Tests Penicillins Kidney Microbiology Anti-Infective Agents Ciprofloxacin Ampicillin medicine Animals Humans Pharmacology (medical) Gram-Positive Bacterial Infections Pharmacology biology Aminoglycoside Endocarditis Bacterial biochemical phenomena metabolism and nutrition biology.organism_classification Drug Resistance Multiple Penicillin Infectious Diseases Enterococcus Vancomycin Drug Therapy Combination Rabbits Spleen medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 36:253-258 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/36.1.253 |
| Popis: | The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecium which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination was used to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci. |
| Databáze: | OpenAIRE |
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