Effects of Irisin and Exercise on Metabolic Parameters and Reproductive Hormone Levels in High-Fat Diet-Induced Obese Female Mice
| Autor: | Faruk Buyru, Cem Celik, Bulent Baysal, Nazli Kubra Okumus, Irem Demiral, Huri Bulut, Ozlem Dural, Ebru Gürel Gürevin, Faruk Çelik, Bahar Yuksel Ozgor, John Yeh, Ercan Bastu, Elif Ilkay Armutak, Umit Zeybek |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Anti-Mullerian Hormone medicine.medical_specialty Ovary Peptide hormone Diet High-Fat Body Mass Index 03 medical and health sciences Mice Weight loss Internal medicine Physical Conditioning Animal medicine Animals Obesity Treadmill business.industry Body Weight Obstetrics and Gynecology Luteinizing Hormone medicine.disease FNDC5 Fibronectins 030104 developmental biology Endocrinology medicine.anatomical_structure Female medicine.symptom Insulin Resistance business Thermogenesis Hormone |
| Zdroj: | Reproductive sciences (Thousand Oaks, Calif.). 25(2) |
| ISSN: | 1933-7205 |
| Popis: | It has been documented that exogenously administered irisin (1010 fibronectin-type III domain-containing 5 [FNDC5]), which is a new polypeptide hormone, induces the browning of subcutaneous fat and thermogenesis. In this study, effects of physical activity and exogenous administration of irisin were investigated on parameters related with reproduction and metabolism in the high-fat diet-induced obesity model of the female C57BL/6J mice. Sixty mice were gathered at age approximately 5 to 6weeks and were divided into 3 groups. Control group remained sedentary. Irisin group remained also sedentary but intravenously received 1010 FNDC5-expressing adenovirus after 20 weeks. Exercise group performed treadmill after 6 weeks. All mice were sacrificed 22 to 23 weeks after the start of the study. There was a significantly greater Δ weight in the controls compared with the irisin and exercise groups ( P .05), whereas primary and secondary follicles per ovary were higher in the irisin and exercise groups compared with controls ( P < .05). Pharmacologic introduction of irisin may improve metabolic factors such as insulin sensitivity and obesity by promoting weight loss and consequently improving the reproductive potential. |
| Databáze: | OpenAIRE |
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