Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India
| Autor: | Preeti Bharaj, Shobha Broor, Sushil K. Kabra, Kavita Diddi, Anubhav Pandey, Lalit Dar, Randeep Guleria, Harendra S. Chahar |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Serotype
Adult Male Dengue hemorrhagic fever Adolescent viruses India Dengue virus Dengue shock syndrome medicine.disease_cause Dengue fever Disease Outbreaks lcsh:Infectious and parasitic diseases Viral genetics Virology medicine Humans lcsh:RC109-216 Severe Dengue Serotyping Child business.industry Reverse Transcriptase Polymerase Chain Reaction Research Infant Newborn Outbreak Infant Dengue Virus medicine.disease Infectious Diseases Child Preschool Immunology RNA Viral Female business |
| Zdroj: | Virology Journal, Vol 5, Iss 1, p 1 (2008) Virology Journal |
| Popis: | Background Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak. Results Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified. Conclusion This is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue. |
| Databáze: | OpenAIRE |
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