The serum bactericidal activity of latamoxef (moxalactam), cefoperazone and cefotaxime
| Autor: | George L. Drusano, H C Standiford, Beverly A. Tatem, William B. McNamee |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Microbiology (medical) Neutropenia Cefotaxime Adolescent medicine.drug_class Klebsiella pneumoniae Antibiotics Cefoperazone Microbial Sensitivity Tests medicine.disease_cause Microbiology chemistry.chemical_compound medicine Humans Pharmacology (medical) Moxalactam Pharmacology Minimum bactericidal concentration Bacteria biology Latamoxef biology.organism_classification Infectious Diseases chemistry Staphylococcus aureus medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 14:491-497 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/14.5.491 |
| Popis: | We determined the serum bactericidal activity 1 h after the end of 2 g, 30 min infusions of latamoxef, cefoperazone and cefotaxime in six volunteers against six strains each of Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. All produced excellent serum bactericidal activity against E. coli. Latamoxef and cefotaxime were superior for K. pneumoniae. Cefoperazone produced the highest titres against Staph. aureus. None of these agents produced sufficient bactericidal activity against Ps. aeruginosa to be useful in initial single agent therapy for the septic, granulocytopenic cancer patient. |
| Databáze: | OpenAIRE |
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