Origin of cholinergic nerves to the rat major cerebral arteries: Coexistence with vasoactive intestinal polypeptide
| Autor: | Geoffrey S. Hamill, David M. Jacobowitz, Hideaki Hara |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Neurons Cholinergic Fibers General Neuroscience Cerebral arteries Immunocytochemistry Vasoactive intestinal peptide Fluorescent Antibody Technique Ganglia Parasympathetic Rats Inbred Strains Anatomy Cerebral Arteries Biology Otic ganglion Acetylcholinesterase Rats chemistry.chemical_compound Cerebral circulation chemistry Animals Cholinergic neuron hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide |
| Zdroj: | Brain Research Bulletin. 14:179-188 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(85)90077-2 |
| Popis: | The distribution and density of vasoactive intestinal polypeptide (VIP) immunoreactive and acetylcholinesterase (AChE)-containing nerves around the cerebral arteries was studied by using whole mounts with or without lesioning the sphenopalatine ganglia. Abundant VIP immunoreactive and AChE-containing nerves were observed around the cerebral blood vessels in normal rats especially in the anterior circulation of the cerebral arteries. VIP-immunoreactivity and AChE-staining was also demonstrated in neurons within the sphenopalatine ganglia. Lesions of the sphenopalatine ganglia resulted in a marked reduction of both VIP-immunoreactivity and AChE activity. In many neurons, coexistence of both VIP and AChE was revealed. These results demonstrate that cholinergic neurons from the sphenopalatine ganglia innervate the cerebral vasculature at the base of the brain, and that VIP and AChE coexists within the same fibers. |
| Databáze: | OpenAIRE |
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