The Associations between Perioperative Blood Transfusion and Long-Term Outcomes after Stomach Cancer Surgery
| Autor: | Fu-Kai Hsu, Wen-Kuei Chang, Kuan-Ju Lin, Wen-Liang Fang, Kuang-Yi Chang, Chunyu Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
dose-response
Cancer Research medicine.medical_specialty Blood transfusion stomach neoplasms disease-free survival Proportional hazards model business.industry Medical record medicine.medical_treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Retrospective cohort study Perioperative blood transfusion medicine.disease Article Surgery survival analysis Oncology medicine Stomach cancer business RC254-282 Survival analysis |
| Zdroj: | Cancers Volume 13 Issue 21 Cancers, Vol 13, Iss 5438, p 5438 (2021) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13215438 |
| Popis: | Background: Whether perioperative packed red blood cell (pRBC) transfusion is associated with inferior long-term outcomes after stomach cancer surgery remains controversial. Methods: This research used a retrospective cohort study. Patients with stage I~III stomach cancer undergoing tumor resection were collected at a tertiary medical center. Patient characteristics, surgical features and pathologic findings were gathered from an electronic medical chart review. The associations of perioperative pRBC transfusion with postoperative disease-free and overall survivals were evaluated using Cox regression analysis with an inverse probability of treatment weighting (IPTW). Restricted cubic spline functions were employed to characterize dose-response relationships between the amount of transfusion and cancer outcomes after surgery. Results: Among the 569 patients, 160 (28.1%) received perioperative pRBC transfusion. Perioperative transfusion was associated with worse disease-free survival (IPTW adjusted HR: 1.42, 95% CI: 1.18–1.71, p < 0.001) and overall survival (IPTW adjusted HR: 1.27, 95% CI: 1.05–1.55, p = 0.014). A non-linear dose-response relationship was noted between the amount of transfusions and worse disease-free or overall survival. Conclusions: Perioperative pRBC transfusion was associated with worse disease-free and overall survival after stomach cancer surgery, and strategies aiming to minimize perioperative transfusion exposure should be further considered to reduce the potential risk. |
| Databáze: | OpenAIRE |
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