Effect of continuous positive airway pressure on liver enzymes in obstructive sleep apnea: A meta-analysis
| Autor: | Jian-Jun Xie, Li-Da Chen, Hui-Xue Zeng, Li Lin, Miao-Feng Hu, Qiyin Wu, Jian-Nan Liu, Liang-Ji Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty medicine.medical_treatment Cochrane Library Gastroenterology Body Mass Index 03 medical and health sciences 0302 clinical medicine Cpap therapy Non-alcoholic Fatty Liver Disease Internal medicine Liver enzyme Nonalcoholic fatty liver disease medicine Immunology and Allergy Humans Continuous positive airway pressure Genetics (clinical) Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry Middle Aged medicine.disease respiratory tract diseases Surgery Obstructive sleep apnea 030228 respiratory system Liver enzyme levels Liver Meta-analysis Female business 030217 neurology & neurosurgery |
| Zdroj: | The clinical respiratory journal. 12(2) |
| ISSN: | 1752-699X |
| Popis: | Background: Previous studies have suggested that obstructive sleep apnea (OSA) was associated with nonalcoholic fatty liver disease (NAFLD). However, the impact of OSA treatment using continuous positive airway pressure (CPAP) on liver enzymes remained controversial. This meta-analysis was conducted to determine whether CPAP therapy could reduce liver enzyme levels. Methods: Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before December 2015. Information on characteristics of subjects, study design and pre- and post-CPAP treatment of serum ALT and AST was extracted for analysis. A total of 5 studies with 7 cohorts that included 192 patients were pooled into meta-analysis. Results: CPAP was associated with a statistically significant decrease on both ALT and AST levels in OSA patients (WMD=8.036, 95% CI=2.788 to 13.285, z=3.00, p=0.003 and WMD=4.612, 95% CI=0.817 to 8.407, z=2.38, p =0.017, respectively). Subgroup analyses indicated that CPAP therapy was more effective in OSA patients with treatment duration>3 months (WMD=12.374, 95% CI=2.727 to 22.020, z=2.51, p=0.012 for ALT and WMD=7.576, 95% CI=1.781 to 13.370, z =2.56, p=0.010 for AST). Conclusion: This meta-analysis suggested that CPAP was associated with a statistically significant decrease on liver enzymes in OSA patients. Further large-scale well-designed RCTs with long-term follow-up are required to clarify this issue. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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