Evaluation of the Clinical Utility of the ICG Fluorescence Method Compared with the Radioisotope Method for Sentinel Lymph Node Biopsy in Breast Cancer
| Autor: | Hironori Kato, Akira Yamauchi, Tecchuu Lee, Hanae Ueyama, Hiroko Bando, Takayuki Kinoshita, Masakazu Toi, Hiroyasu Yamashiro, Takafumi Ikeda, Kenichi Yoshimura, Katsumasa Kuroi, Nobuhiko Shinkura, Tetsuya Taguchi, Tomoharu Sugie, Terumasa Sawada, Norikazu Masuda |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Indocyanine Green Pathology medicine.medical_specialty genetic structures Sentinel lymph node Coloring agents Breast Neoplasms 030230 surgery Fluorescence Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Biopsy Humans Medicine Neoplasm Invasiveness Prospective Studies Coloring Agents Radionuclide Imaging Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Follow up studies Organotechnetium Compounds Middle Aged Prognosis medicine.disease eye diseases Oncology Multicenter study chemistry 030220 oncology & carcinogenesis Female Surgery Neoplasm staging Lymph Nodes Radiopharmaceuticals business Nuclear medicine Indocyanine green Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 23:44-50 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | This study compared the clinical utility of indocyanine green (ICG) fluorescence and radioisotope (RI) for sentinel lymph node (SLN) detection in breast cancer.Women with node-negative breast cancer underwent SLN biopsy using ICG fluorescence and RI. The primary end point was the sensitivity of ICG fluorescence compared with RI in the patients with tumor-positive SLNs. Secondary end points included detection rates for SLN, the additive effect of ICG fluorescence to RI, signature of positive SLNs according to tier, and adverse events related to ICG administration.A total of 847 women with clinical node-negative breast cancer underwent SLN biopsy, and 821 patients were included in the per-protocol analysis. SLN mapping was performed using ICG fluorescence and RI. The overall detection of SLNs using ICG fluorescence was identical to RI (97.2 vs. 97.0 %, P = 0.88), and the combination of both methods achieved a significant improvement compared with RI alone (99.8 vs. 97.0 %, P0.001). The detection rate for tumor-positive SLN was 93.3 % for ICG fluorescence and 90.0 % for RI, and the sensitivity of the ICG fluorescence method was 95.7 % (95 % CI 91.3-98.3, P = 0.11). The additional use of ICG significantly improved positive SLN detection for RI (97.2 vs. 90.0 %, P0.001). There were no serious adverse events related to hypersensitivity to ICG.The ICG fluorescence method may be an acceptable alternative to SLN detection using RI in breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink