Responsiveness to parenteral iron therapy in children with oral iron-refractory iron-deficiency anemia
| Autor: | Cem Karadeniz, Bilal Yilmaz, Yasin Tugrul Karakus, Osman Oztekin, Mehmet Akin, Enver Atay, Fırat Erdoğan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Erythrocyte Indices
Male Sucrose medicine.medical_specialty Pediatrics Adolescent Anemia Iron Ferritin levels Drug Resistance Administration Oral Ferric Compounds Gastroenterology IRIDA Glucaric Acid Internal medicine Humans Medicine Ferrous Compounds Child Infusions Intravenous FERRIC IRON Ferric Oxide Saccharated Iron-Refractory Iron Deficiency Anemia Anemia Iron-Deficiency biology business.industry Hematology medicine.disease Ferritin Treatment Outcome Oncology Child Preschool Pediatrics Perinatology and Child Health biology.protein Female Hemoglobin business Parenteral iron Iron therapy |
| Popis: | WOS: 000331063500007 PubMed ID: 24087940 Intravenous (IV) ferric iron (Fe)-carbohydrate complexes are used for treating Fe deficiency in children with iron-refractory iron-deficiency anemia (IRIDA). An optimal treatment has yet to be determined. There are relatively little publications on the responsiveness to IV iron therapy in children with IRIDA. Patients and Method: This study analyzed responses to IV iron sucrose therapy given to 11 children, ranging in age from 2 to 13 years (mean 4.8 years), with iron-deficiency anemia who were unresponsive to oral iron therapy. Results: The hemoglobin and ferritin values (mean) of the 11 children with IRIDA were 7.7 g/dL and 4.8 ng/mL at diagnosis. Both hemoglobin and ferritin levels increased to 9.5 g/dL, and 24 ng/mL, respectively, at 6 weeks after the first therapy. Although the level of hemoglobin was steady at 6 months after the first, and 6 weeks after the second therapy, the ferritin levels continued to increase up to 30 ng/mL and 47 ng/mL at 6 months after the first and 6 weeks after the second therapy, respectively. Conclusion: We recommend that IRIDA should be considered in patients presenting with iron-deficiency anemia of unknown cause that is unresponsive to oral iron therapy. Our results suggest that IV iron therapy should be administered only once in cases of IRIDA. Continued administration of IV iron would be of no benefit to increase hemoglobin levels. On the contrary, ferritin levels may continue to increase resulting in untoward effects of hyperferritinemia. |
| Databáze: | OpenAIRE |
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