Inhibition of the RANKL with denosumab has no effect on circulating markers of atherosclerosis in women with postmenopausal osteoporosis: a pilot study
| Autor: | Sara Piemonte, Valentina Piazzolla, Viviana De Martino, Salvatore Minisola, Federica Ferrone, Luciano Nieddu, Luciano Colangelo, Jessica Pepe, Daniele Diacinti, Valeria Fassino, Cristiana Cipriani |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
P-selectin atherosclerosis cardiovascular Denosumab osteoporosis postmenopausal Endocrinology Diabetes and Metabolism Osteoporosis Pilot Projects 030209 endocrinology & metabolism Fibrinogen 03 medical and health sciences 0302 clinical medicine Endocrinology Bone Density Diabetes mellitus Internal medicine Humans Medicine Osteoporosis Postmenopausal Aged Aged 80 and over Bone Density Conservation Agents biology business.industry Monocyte medicine.disease medicine.anatomical_structure Zoledronic acid RANKL 030220 oncology & carcinogenesis biology.protein Female business medicine.drug |
| Zdroj: | Endocrine. 71:199-207 |
| ISSN: | 1559-0100 1355-008X |
| Popis: | We evaluated the early effect of denosumab on circulating markers of atherosclerosis in women with postmenopausal osteoporosis. Denosumab (60 mg) was administered subcutaneously every 6 months (m) in 27 women (mean age 75 ± 5 years) with postmenopausal osteoporosis and high cardiovascular risk for a total of 24 m. Zoledronic acid was administered in 6 age-matched women as a single intravenous dose. Serum levels of vascular cell adhesion protein 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E and P selectin, CD-40 ligand (CD40L), interleukin-6 (IL-6), matrix metalloproteinase (MMP) 1 and 9, monocyte chemoattractant protein-1 (MCP-1), fibrinogen (FBG), and high sensitivity C-reactive protein (hs-CRP) were measured at baseline, 15 days (d), 2, 6 and 12 m after dosing. In the denosumab group, observation was extended to 24 m as secondary endpoint. Serum ICAM-1 levels showed significant increase in the zoledronic acid group (+18 ± 0.1%; p |
| Databáze: | OpenAIRE |
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