Abrusosides A-D, Four Novel Sweet-Tasting Triterpene Glycosides from the leaves of Abrus precatorius
| Autor: | A. D. Kinghorn, Young-Hee Choi, Raouf A. Hussain, John M. Pezzuto, J. F. Morton |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Salmonella typhimurium Taste Magnetic Resonance Spectroscopy Sucrose Stereochemistry Molecular Sequence Data Pharmaceutical Science Biology Pharmacognosy Analytical Chemistry Mice chemistry.chemical_compound Triterpene Abrus precatorius Drug Discovery Botany Animals Glycosides Pharmacology chemistry.chemical_classification Mutagenicity Tests Organic Chemistry Glycoside Plants Sweetness biology.organism_classification Triterpenes carbohydrates (lipids) Aglycone Carbohydrate Sequence Complementary and alternative medicine chemistry Sweetening Agents Molecular Medicine |
| Zdroj: | Journal of Natural Products. 52:1118-1127 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50065a032 |
| Popis: | In addition to abrusoside A [1], abrusosides B [2], C [3], and D [4], three further sweet glycosides based on the novel cycloartane-type aglycone, abrusogenin [5], were isolated from an n-BuOH-soluble extract of the leaves of Abrus precatorius. Using a combination of spectral methods, the structures of compounds 1-4 were assigned, respectively, as the 3-O-beta-D-glucopyranosyl, the 3-O-beta-D-glucopyranosyl-(1----2)-beta-D-6-methylglucuronopyranosyl+ ++, the 3-O-beta-D-glucopyranosyl-(1----2)-beta-D-glucopyranosyl, and the 3-O-beta-D-glucopyranosyl-(1----2)-beta-D-glucuronopyranosyl derivatives of compound 5. After it established that compounds 1-4 were neither acutely toxic with mice nor mutagenic with Salmonella typhimurium strain TM677, they were found by a human taste panel to exhibit sweetness potencies in the range 30-100 times greater than sucrose. |
| Databáze: | OpenAIRE |
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