TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES

Autor:	Allan Lipton, R. P. Walker, B. C. Langton, Y. L. Matthews, H. Al-Mondhiry, J. R. Dasch, L. M. Witters
Rok vydání:	1994
Předmět:	Oncology Cancer Research medicine.medical_specialty TGF alpha Oncogene business.industry Cell Cancer Cell cycle medicine.disease_cause medicine.disease Molecular medicine medicine.anatomical_structure Apoptosis Internal medicine medicine Carcinogenesis business
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
Popis:	Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654929ddfafa1ded719278af649d9020 https://doi.org/10.3892/ijo.4.4.943 Zobrazit plný text záznamu