Remodeling the tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin
| Autor: | Linwei Kan, Xiangfeng Yue, Min Li, Yu Wang, Jing Zhang, Ziwei Jing |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cell Survival
Biomedical Engineering Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Mice chemistry.chemical_compound Neoplasms Hyaluronic acid Tumor Microenvironment medicine Animals Humans Neoplasm General Materials Science Doxorubicin Hyaluronic Acid Metal-Organic Frameworks Drug Carriers Tumor microenvironment biology CD44 Hep G2 Cells General Chemistry General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology medicine.disease Nanostructures 0104 chemical sciences Drug Liberation Hyaluronan Receptors chemistry Drug Resistance Neoplasm Zeolites biology.protein Cancer research Quercetin 0210 nano-technology Zeolitic imidazolate framework medicine.drug Homing (hematopoietic) |
| Zdroj: | Journal of Materials Chemistry B. 7:7619-7626 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | The tumor microenvironment (TM) plays a critical role in the progress of tumors. However, the TM remodeling effects of currently available therapies remain largely unexplored in many previous reports. In our study, a hyaluronic acid (HA)-modified zeolitic imidazolate framework (ZIF) was successfully fabricated (HA/ZIF) and employed to load doxorubicin (Dox) and quercetin (Que) simultaneously for cancer therapy. The Que and Dox co-loaded HA/ZIF (HA/ZIF/DQ) showed preferable stability under physiological conditions, pH-responsive drug release in an acidic environment and preferential homing capacity to the CD44 receptor-overexpressed HepG2/ADR cells. More importantly, our results revealed that enhanced anticancer efficacy was achieved through the combination of Que and Dox via the tumor microenvironment remodeling effect of Que to potentiate drug penetration into deep tumor tissues. |
| Databáze: | OpenAIRE |
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