Effects of Cyclophosphamide Pulse Therapy on the Clinical and Histopathological Findings, Particularly Crescent Formation, in a Patient with Adult-onset Steroid-refractory Henoch-Schönlein Purpura Nephritis
| Autor: | Wataru Yoshimoto, Takurou Yano, Mari Moribata, Asuka Masumoto, Takashi Shigematsu, Shintaro Yamanaka, Koichi Tatsuta, Toshifumi Sakaguchi, Daisuke Koreeda, Yoshiyuki Hanba, Yuri Nakashima, Yusuke Tanaka, Toru Mima, Shuto Yamamoto, Shigeo Negi, Sou Kobayashi, Koji Masumoto, Masaki Ohya |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Henoch-Schonlein purpura IgA Vasculitis Cyclophosphamide urologic and male genital diseases Gastroenterology Nephritic syndrome Heart Rate Internal medicine Internal Medicine medicine Humans Monitoring Physiologic Nephritis medicine.diagnostic_test business.industry Remission Induction General Medicine medicine.disease Purpura Treatment Outcome Pulse Therapy Drug Immunology Mesangial proliferative glomerulonephritis Female Steroids Histopathology Renal biopsy medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Internal Medicine. 54:2207-2211 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission. Cyclophosphamide pulse therapy may be considered an effective treatment for intractable HSPN. |
| Databáze: | OpenAIRE |
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