Increased Risk of Oncogenic Human Papillomavirus Infections and Incident High-Grade Cervical Intraepithelial Neoplasia Among Smokers
| Autor: | Luis Otávio Sarian, Cecilia Roteli-Martins, Jean Carlos de Matos, Kari Syrjänen, Silvano Costa, Renata Guarisi, Luciano Serpa Hammes, Silvio Tatti, Mojca Eržen, Adhemar Longatto-Filho, Margherita Branca, Renata Clementino Gontijo, Stina Syrjänen, Marina Y. S. Maeda, Sophie Françoise Mauricette Derchain, Paulo Naud, Temístocles P. Lima |
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| Přispěvatelé: | [et al.], Universidade do Minho |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Microbiology (medical) Sexually transmitted disease medicine.medical_specialty medicine.medical_treatment Argentina Uterine Cervical Neoplasms Dermatology Cervical intraepithelial neoplasia Risk Factors Internal medicine Prevalence medicine Humans Cervical Intraepithelial Neoplasia Risk factor Cervical cancer Gynecology Science & Technology business.industry Incidence Incidence (epidemiology) Papillomavirus Infections Smoking Hazard ratio Public Health Environmental and Occupational Health Middle Aged Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Infectious Diseases High Grade Cervical Intraepithelial Neoplasia Smoking cessation Female business Brazil |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0148-5717 |
| DOI: | 10.1097/olq.0b013e3181935a7d |
| Popis: | Background: The purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-HPV) infection and cervical intraepithelial neoplasia (CIN) in a large sample of Latin American women. Methods: The study examines baseline data on over 12,000 women included in the Latin American Screening Study (Brazil and Argentina), and over 1000 women followed-up for a period of 36 months. Three groups were formed: never smokers, current, and past smokers. The prevalence of hr-HPV infection and CIN were compared between the study groups. In the prospective analysis, women were controlled at 6-month intervals to assess the cumulative risk of incident hr-HPV infection, smear abnormalities, and CIN. Results: A higher prevalence (21.7%) of hr-HPV infection was found among current smokers as compared to never smokers (16.5%) or past smokers (13.5%). Being current smoker was significantly (P Supported by the INCO-DEV Program of the European Commission (Project No. ICA4-CT-2001-10013). |
| Databáze: | OpenAIRE |
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