Evaluation of the thyroid disorders in children with familial Mediterranean fever
| Autor: | Hande Turan, Orkun Civan, Ibrahim Adaletli, Kenan Barut, Mine Kucur, Mehmet Yildiz, Oya Ercan, Yavuz Ozer, Saadet Olcay Evliyaoğlu, Aydilek Dagdeviren Cakir, Ozgur Kasapcopur, Zerengiz Bayramli, Gurkan Tarcin, Amra Adrovic |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Familial Mediterranean fever Thyrotropin Thyroid function tests 03 medical and health sciences 0302 clinical medicine Rheumatology Thyroid peroxidase Internal medicine medicine Humans 030212 general & internal medicine Child 030203 arthritis & rheumatology biology medicine.diagnostic_test business.industry Thyroid General Medicine medicine.disease Thyroid Diseases Anti-thyroid autoantibodies Familial Mediterranean Fever Thyroxine medicine.anatomical_structure Immunology biology.protein Thyroglobulin business Hormone |
| Zdroj: | Clinical rheumatology. 40(4) |
| ISSN: | 1434-9949 |
| Popis: | Although it is well-known that autoimmune thyroid diseases are more common in most of the autoimmune connective tissue diseases, the relationship between autoinflammatory diseases and autoimmune thyroid diseases has not well-evaluated yet and still remains unclear. The aim of this study was to investigate the frequency of autoimmune diseases of the thyroid gland and to evaluate thyroid function tests in children with familial Mediterranean fever. Thyroxine, thyroid-stimulating hormone, and thyroid autoimmune markers such as thyroid peroxidase and thyroglobulin antibodies, and thyroid ultrasound findings of 133 patients with familial Mediterranean fever and 70 healthy controls were evaluated. Serum levels of thyroid-stimulating hormone, free thyroxine, and thyroid autoimmunity markers were similar in patients with familial Mediterranean fever compared with healthy controls. There was no relationship between the duration of the disease and thyroid-stimulating hormone, free thyroxine, anti-thyroid peroxidase, and anti-thyroglobulin levels. This study revealed that incidence of thyroid dysfunction and autoimmunity is not increased in patients with familial Mediterranean fever. In conclusion, routine screening of serum thyroid function tests and thyroid antibody levels is not required in patients with familial Mediterranean fever in the absence of clinical symptoms or family history. Key Points • It is well-known that autoimmune thyroid diseases are common in autoimmune diseases. • The relationship between autoimmune thyroid diseases and autoinflammatory diseases like familial Mediterranean fever is still unclear. • In this study, we report the similar frequency of the autoinflammatory thyroid diseases in patients with familial Mediterranean fever and healthy controls. • A routine screening of serum thyroid function tests and thyroid antibody levels may not be required in patients with familial Mediterranean fever in the absence of clinical symptoms or family history. |
| Databáze: | OpenAIRE |
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