Serum Concentrations of Penicillin Following the Administration of Crystalline Procaine Penicillin G in Oil
| Autor: | Chester S. Keefer, Philip Whittlesey, William L. Hewitt |
|---|---|
| Rok vydání: | 1948 |
| Předmět: |
Chromatography
medicine.drug_class business.industry Sodium Potassium Antibiotics Procaine Hydrochloride chemistry.chemical_element Penicillin G Procaine Penicillins General Medicine Benzylpenicillin Penicillin Procaine Blood serum Biochemistry chemistry polycyclic compounds medicine Humans business medicine.drug |
| Zdroj: | New England Journal of Medicine. 239:286-290 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm194808192390802 |
| Popis: | THE use of peanut oil and beeswax suspensions of amorphous calcium penicillin and of the sodium and potassium salts of crystalline penicillin G for delaying its absorption when injected intramuscularly is well known. The recent preparation of the crystalline procaine salt of penicillin G has afforded the opportunity for studying the absorption of a relatively insoluble salt.1 , 2 Procaine penicillin is a true salt derived by the stoechiometric combination of procaine hydrochloride and sodium penicillin G. Calculated on the basis of a potency for crystal-line sodium penicillin G at 1667 units per milligram, the theoretical potency of crystalline procaine penicillin G . . . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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