Detection of Rotavirus Genotypes in Korea 5 Years after the Introduction of Rotavirus Vaccines
| Autor: | Tae Woong Jung, Jong Hyun Kim, Doo Sung Cheon, Ju Young Chung, Dae Sun Jo, Hwang Min Kim, Jae Hong Park, Sang Hyuk Ma, Hye Sook Jeong, Seung Beom Han, Min-Sung Kim, Jin Han Kang, Seong Joon Kim, Jung Woo Rhim, Sang Yong Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Rotavirus
Genotype Biology medicine.disease_cause Vaccines Attenuated Pediatrics Mass Vaccination Rotavirus Infections law.invention Feces law Republic of Korea medicine Humans Children Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction Incidence (epidemiology) Rotavirus Vaccines Outbreak Infant General Medicine Acute gastroenteritis Virology Gastroenteritis Vaccination Child Preschool RNA Viral Original Article Vaccine |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Rotavirus (RV) is one of the most important viral etiologic agents of acute gastroenteritis (AGE) in children. Although effective RV vaccines (RVVs) are now used worldwide, novel genotypes and outbreaks resulting from rare genotype combinations have emerged. This study documented RV genotypes in a Korean population of children with AGE 5 yr after the introduction of RVV and assessed potential genotype differences based on vaccination status or vaccine type. Children less than 5-yr-old diagnosed with AGE between October 2012 and September 2013 admitted to 9 medical institutions from 8 provinces in Korea were prospectively enrolled. Stool samples were tested for RV by enzyme immunoassay and genotyped by multiplex reverse-transcription polymerase chain reaction. In 346 patients, 114 (32.9%) were RV-positive. Among them, 87 (76.3%) patients were infected with RV alone. Eighty-six of 114 RV-positive stool samples were successfully genotyped, and their combinations of genotypes were G1P[8] (36, 41.9%), G2P[4] (12, 14.0%), and G3P[8] (6, 7.0%). RV was detected in 27.8% of patients in the vaccinated group and 39.8% in the unvaccinated group (P=0.035). Vaccination history was available for 67 of 86 cases with successfully genotyped RV-positive stool samples; RotaTeq (20, 29.9%), Rotarix (7, 10.4%), unvaccinated (40, 59.7%). The incidence of RV AGE is lower in the RV-vaccinated group compared to the unvaccinated group with no evidence of substitution with unusual genotype combinations. Graphical Abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|