Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice
| Autor: | Ito Tetsuya, Eriko Kishino, Hisaharu Masaki, Naho Takemura, Masatoshi Nakazawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
lactosucrose
Immunology medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Cecum Immune system medicine Influenza A virus Cytotoxic T cell Feces cytotoxic activity Innate immune system Full Paper business.industry splenic NK cells Lethal dose Gastroenterology Titer medicine.anatomical_structure secretory IgA serum IgA mucosal immunity business Food Science |
| Zdroj: | Bioscience of Microbiota, Food and Health |
| ISSN: | 2186-3342 2186-6953 |
| Popis: | This study examined the effects of lactosucrose (4(G)-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4(+) T cells in Peyer's patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity. |
| Databáze: | OpenAIRE |
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