Immunoinfertility: A Case Study with Implications for Immunocontraception
| Autor: | H. W. G. Baker, De Yi Liu, G. N. Clarke |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Infertility Blotting Western Semen Fertilization in Vitro Antibodies Andrology Endocrinology Antigen Immunity Complementary DNA medicine Humans Infertility Male Zona Pellucida Sperm-Ovum Interactions Immunocontraception biology medicine.disease Spermatozoa Sperm Contraception Immunoglobulin G Cervix Mucus Oocytes biology.protein Electrophoresis Polyacrylamide Gel Female Antibody |
| Zdroj: | Archives of Andrology. 35:21-27 |
| ISSN: | 0148-5016 |
| DOI: | 10.3109/01485019508987849 |
| Popis: | A detailed case history was compiled on a couple who have had primary infertility for more than 20 years. The history and further laboratory investigations indicated that the infertility was caused by high-titre sperm antibodies in the female. The antibodies blocked sperm-zona binding and reacted with a prominent band at 65 kD in Western blots. Preliminary studies indicate that a subset of the patient's antibodies are specific for a unique protein sequence expressed by a cDNA testis library. This antigen may have potential for immunocontraceptive vaccine development. |
| Databáze: | OpenAIRE |
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