Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men
| Autor: | Ben Eggeling, M. Lagerpusch, Janna Enderle, Judith Karschin, Anja Bosy-Westphal, Manfred J. Müller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Science Random Allocation Young Adult Insulin resistance Internal medicine Glycemic load Insulin Secretion medicine Hyperinsulinemia Humans Insulin skin and connective tissue diseases Glucose tolerance test Multidisciplinary Adiponectin medicine.diagnostic_test business.industry Leptin Body Weight Fasting Glucose Tolerance Test medicine.disease Diet Endocrinology Body Composition Medicine Ghrelin sense organs Insulin Resistance business hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 2, p e0117865 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | ObjectiveChanges in insulin sensitivity (IS) and insulin secretion occur with perturbations in energy balance and glycemic load (GL) of the diet that may precede the development of insulin resistance and hyperinsulinemia. Determinants of changes in IS and insulin secretion with weight cycling in non-obese healthy subjects remain unclear.MethodsIn a 6wk controlled 2-stage randomized dietary intervention 32 healthy men (26±4y, BMI: 24±2kg/m2) followed 1wk of overfeeding (OF), 3wks of caloric restriction (CR) containing either 50% or 65% carbohydrate (CHO) and 2wks of refeeding (RF) with the same amount of CHO but either low or high glycaemic index at ±50% energy requirement. Measures of IS (basal: HOMA-index, postprandial: Matsuda-ISI), insulin secretion (early: Stumvoll-index, total: tAUC-insulin/tAUC-glucose) and potential endocrine determinants (ghrelin, leptin, adiponectin, thyroid hormone levels, 24h-urinary catecholamine excretion) were assessed.ResultsIS improved and insulin secretion decreased due to CR and normalized upon RF. Weight loss-induced improvements in basal and postprandial IS were associated with decreases in leptin and increases in ghrelin levels, respectively (r = 0.36 and r = 0.62, pConclusionWeight cycling induced changes in IS and insulin secretion were associated with changes in all measured hormones, except for catecholamine excretion. While leptin, adiponectin and ghrelin seem to be the major endocrine determinants of IS, leptin/adiponectin-ratio and fT4 levels may impact changes in insulin secretion with weight cycling.Trial registrationClinicalTrials.gov NCT01737034. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|