Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity: an observational case-control study

Autor: Jian-Jun Li, Feng Gao, Jia-Yi Liu, Ya-Jing Li, Xin-Ying Cong, Zuliyaer Talifu, Xin Zhang
Rok vydání: 2022
Předmět:
Zdroj: Neural regeneration research. 18(3)
ISSN: 1673-5374
Popis: Spinal cord injury is a severe and devastating disease, and spasticity is a common and severe complication that is notoriously refractory to treatment. However, the pathophysiological mechanisms underlying spasticity and its development remain largely unknown. The goal of the present study was to find differences, if any, in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity, and to explore the relationship between the brain metabolite concentrations and clinical status. Thirty-six participants were recruited for magnetic resonance spectroscopic examination: 23 with spinal cord injury (12 with spasticity and 11 without spasticity) and 13 healthy controls. We acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm
Databáze: OpenAIRE