Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress
| Autor: | Zhenxiang Li, Jiamao Lin, Lijun Fang, Linmao Lyu, Haiyong Wang, Jun Xiao, Hui Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Cardiac fibrosis Cardiomyopathy Pharmacology medicine.disease_cause 03 medical and health sciences Mice 0302 clinical medicine polycyclic compounds medicine Animals Doxorubicin Myocytes Cardiac Cell Size Cardiotoxicity NADPH oxidase biology business.industry Body Weight NOX4 Organ Size Saponins medicine.disease Triterpenes Rats carbohydrates (lipids) Oxidative Stress 030104 developmental biology Gene Expression Regulation Apoptosis NADPH Oxidase 4 NADPH Oxidase 2 cardiovascular system biology.protein business Cardiomyopathies 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | European journal of pharmacology. 859 |
| ISSN: | 1879-0712 |
| Popis: | Doxorubicin (DOX) is a classic anti-tumor chemotherapeutic used to treat a wide range of tumors. One major downfall of DOX treatment is it can induce fatal cardiotoxicity. Astragaloside IV (AS-IV) is one of the primary active ingredients that can be isolated from the traditional Chinese herbal medicine, Astragalus membranaceus. This study uses both in vitro and in vivo tools to investigate whether AS-IV alleviates DOX induced cardiomyopathy. We found that AS-IV supplementation alleviates body weight loss, myocardial injury, apoptosis of cardiomyocytes, cardiac fibrosis and cardiac dysfunction in DOX-treated mice. Also, DOX-induced cardiomyocyte injury and apoptosis were effectively improved by AS-IV treatment in vitro. NADPH oxidase (NOX) plays an important role in the progress of the oxidative signal transduction and DOX-induced cardiomyopathy. In this study, we found that AS-IV treatment relieves DOX-induced NOX2 and NOX4 expression and oxidative stress in cardiomyocytes. In conclusion, AS-IV, an antioxidant, attenuates DOX-induced cardiomyopathy through the suppression of NOX2 and NOX4. |
| Databáze: | OpenAIRE |
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