Bactericidal activity of tuftsin
| Autor: | Francois Winternitz, Jean Martinez |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Staphylococcus aureus
Phagocytosis Guinea Pigs Clinical Biochemistry Tuftsin medicine.disease_cause Microbiology Mice Saccharomyces chemistry.chemical_compound Dogs Listeria monocytogenes In vivo medicine Animals Ascitic Fluid Humans Immunoglobulin Fragments Molecular Biology Bacteria biology Tetrapeptide Chemistry Nitroblue Tetrazolium Cell Biology General Medicine biology.organism_classification In vitro Liver Serratia marcescens Rabbits Spleen |
| Zdroj: | Molecular and Cellular Biochemistry. 41 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/bf00225303 |
| Popis: | The biological activities of the phagocytosis stimulating tetrapeptide, Thr-Lys-Pro-Arg are discussed. A brief account on the stimulation by tuftsin of phagocytosis of various particles, including bacteria was reported. Stimulation of bactericidal activity by this tetrapeptide was investigated in vitro as well as in vivo. The potency of tuftsin to enhance blood clearing of Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Serratia marcescens by mouse peritoneal macrophages was demonstrated. Bactericidal activity and effects of tuftsin on this phenomenon were studied in liver and spleen of mice. Tuftsin stimulates these activities. Same experiments were performed in infected leukemic mice by Serratia marcescens or Escherichia coli. Results on blood clearing and bactericidal activities in liver and spleen were reported and compared to those of healthy and leukemic untreated animals. Tuftsin was found to present interesting stimulatory effects on the bactericidal activity of phagocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink