Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder

Autor:	Peter Falkai, Juliana Usher, Oliver Gruber, Harald Scherk, C. Kemmer, Wolfgang Reith, Martin Backens, Thomas Schneider-Axmann
Rok vydání:	2008
Předmět:	Adult Male Pathology medicine.medical_specialty Bipolar Disorder Bipolar I disorder Thalamus Central nervous system Hippocampus Hippocampal formation Choline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine mental disorders medicine Humans Bipolar disorder Aspartic Acid Putamen Creatine medicine.disease 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure nervous system chemistry Female Dysthymic Disorder Psychology Inositol 030217 neurology & neurosurgery
Zdroj:	Acta Psychiatrica Scandinavica. 117:283-288
ISSN:	1600-0447 0001-690X
Popis:	Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent. Method: N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated. Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen. Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6536e07513d47feb936fb69a35b466b2 https://doi.org/10.1111/j.1600-0447.2007.01142.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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