Hyperinflation With Pulmonary Dysfunction in Donor Lungs With Smoking History During Lung Perfusion
| Autor: | J. Steven Hata, Carol Farver, Kenneth R. McCurry, Hiroshi Yabuki, Toshihiro Okamoto, Kamal S. Ayyat, Hiromichi Niikawa, Yoshifumi Itoda |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Tissue and Organ Procurement Hyperinflation Pulmonary compliance Pulmonary Dysfunction Smoking history 03 medical and health sciences 0302 clinical medicine Internal medicine Fraction of inspired oxygen Tidal Volume medicine Humans Lung Aged business.industry Smoking Lung perfusion Organ Preservation Middle Aged respiratory system Allografts Tissue Donors Donor lungs Perfusion medicine.anatomical_structure Exhalation 030220 oncology & carcinogenesis Cardiology Female 030211 gastroenterology & hepatology Surgery business Lung Transplantation |
| Zdroj: | Journal of Surgical Research. 255:502-509 |
| ISSN: | 0022-4804 |
| Popis: | Background Donor lungs with smoking history are perfused in ex vivo lung perfusion (EVLP) to expand donor lung pool. However, the impact of hyperinflation of perfused lungs in EVLP remains unknown. The aim of this study was to investigate the significance of hyperinflation, using an ex vivo measurement delta VT, during EVLP in smoker's lungs. Materials and methods Seventeen rejected donor lungs with smoking history of median 10 pack-years were perfused for 2 h in cellular EVLP. Hyperinflation was evaluated by measuring delta VT = inspiratory − expiratory tidal volume (VT) difference at 1 h. All lungs were divided into two groups; negative delta VT (n = 11, no air-trapping pattern) and positive delta VT (n = 6, air-trapping pattern). Transplant suitability was judged at 2 h. By using lung tissue, linear intercept analysis was performed to evaluate the degree of hyperinflation. Results The positive delta VT group had significantly lower transplant suitability than the negative delta VT group (16 versus 81%, P = 0.035). The positive delta VT group was significantly associated with lower partial pressure of oxygen/fraction of inspired oxygen ratio ratio (278 versus 356 mm Hg, P = 0.049), higher static compliance (119 versus 98 mL/cm H2O, P = 0.050), higher lung weight ratio (1.10 versus 0.96, P = 0.014), and higher linear intercept ratio (1.52 versus 0.93, P = 0.005) than the negative delta VT group. Conclusions Positive delta VT appears as an ex vivo marker of ventilator-associated lung hyperinflation of smoker's lungs during EVLP. |
| Databáze: | OpenAIRE |
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