PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS
Autor: | Brandon Jansonius, Stefan M. Pfister, Marc Remke, Gabriel Leprivier, Marcel Kool, Jonathan K M Lim, Michael D. Taylor, Asad Jan, Poul H. Sorensen, John M. Maris, Alberto Delaidelli, Gian Luca Negri |
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Rok vydání: | 2017 |
Předmět: | |
Zdroj: | Neuro-Oncology. 19:vi199-vi200 |
ISSN: | 1523-5866 1522-8517 |
Popis: | BACKGROUND/OBJECTIVES MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN and c-MYC amplification in childhood neuroblastoma (NB) and medulloblastoma (MB) are associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for these tumors. MYC-driven oncogenic transformation impairs cell survival under nutrient deprivation (ND), a characteristic stress condition within the tumor microenvironment. We recently identified eukaryotic Elongation Factor 2 Kinase (eEF2K) as a pivotal mediator of the adaptive response of tumor cells to ND. We therefore hypothesized that eEF2K facilitates the adaptation of MYCN/MYC amplified NB/MB to ND, and that inhibiting this pathway can impair tumor progression. |
Databáze: | OpenAIRE |
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