PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS

Autor:	Brandon Jansonius, Stefan M. Pfister, Marc Remke, Gabriel Leprivier, Marcel Kool, Jonathan K M Lim, Michael D. Taylor, Asad Jan, Poul H. Sorensen, John M. Maris, Alberto Delaidelli, Gian Luca Negri
Rok vydání:	2017
Předmět:	Medulloblastoma Cancer Research Tumor microenvironment Tissue microarray Cancer Biology medicine.disease Abstracts Mediator Oncology Tumor progression Neuroblastoma medicine Cancer research Neurology (clinical) Childhood Neuroblastoma
Zdroj:	Neuro-Oncology. 19:vi199-vi200
ISSN:	1523-5866 1522-8517
Popis:	BACKGROUND/OBJECTIVES MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN and c-MYC amplification in childhood neuroblastoma (NB) and medulloblastoma (MB) are associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for these tumors. MYC-driven oncogenic transformation impairs cell survival under nutrient deprivation (ND), a characteristic stress condition within the tumor microenvironment. We recently identified eukaryotic Elongation Factor 2 Kinase (eEF2K) as a pivotal mediator of the adaptive response of tumor cells to ND. We therefore hypothesized that eEF2K facilitates the adaptation of MYCN/MYC amplified NB/MB to ND, and that inhibiting this pathway can impair tumor progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6535ea4c228a9c89890144d1564e518c https://doi.org/10.1093/neuonc/nox168.808 Zobrazit plný text záznamu