The role of herpesvirus entry mediator as a negative regulator of T cell–mediated responses
| Autor: | Klaus Pfeffer, Daniel Degrandi, Karin Mink, Sarah E. Blink, Yonglian Sun, Xiaojuan Liu, James C. Lo, Yugang Wang, Jing Wang, Yang Wang, Yang Xin Fu, Sumit K. Subudhi, Robert A. Anders |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Herpesvirus entry mediator
Tumor Necrosis Factor Ligand Superfamily Member 14 Encephalomyelitis Autoimmune Experimental medicine.medical_treatment T cell T-Lymphocytes Lymphocyte Activation Article Receptors Tumor Necrosis Factor Mice Immune system medicine Concanavalin A Cytotoxic T cell Animals Humans IL-2 receptor Receptor Mice Knockout biology Tumor Necrosis Factor-alpha Membrane Proteins General Medicine Mice Inbred C57BL Survival Rate Cytokine medicine.anatomical_structure Liver Immunology biology.protein Cytokines Receptors Virus Disease Susceptibility Receptors Tumor Necrosis Factor Member 14 Spleen |
| Popis: | Herpesvirus entry mediator (HVEM), a TNF receptor superfamily member, has been previously described as a T cell costimulatory receptor. Surprisingly, HVEM-/- T cells showed enhanced responses to in vitro concanavalin A (ConA) stimulation when compared with WT T cells. Consistent with these findings, HVEM-/- mice exhibited increased morbidity and mortality as compared with WT mice in a model of ConA-mediated T cell-dependent autoimmune hepatitis. HVEM-/- mice produced higher levels of multiple cytokines, which were dependent on the presence of CD4+ T cells. Furthermore, HVEM-/- mice were more susceptible to MOG peptide-induced experimental autoimmune encephalopathy, and they showed increased T cell proliferation and cytokine production in response to antigen-specific challenge. Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|