Effects of Nisoldipine on Coronary Collateral Perfusion and Hemodynamics in Chronically Instrumented Dogs
| Autor: | David C. Warltier, Harold L. Brooks, J C Hartman, Dermot Kenny |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Nifedipine Nisoldipine Hemodynamics Blood Pressure Dogs Heart Rate Coronary Circulation Internal medicine Heart rate medicine Animals Ultrasonics Cardiac Output Pharmacology business.industry Dihydropyridine General Medicine Blood flow Calcium Channel Blockers Collateral circulation Blood pressure Cardiology Female business Perfusion medicine.drug |
| Zdroj: | Pharmacology. 38:263-271 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000138545 |
| Popis: | The effects of a new dihydropyridine slow-channel calcium blocking agent, nisoldipine, on hemodynamics and myocardial blood flow in normal and collateral-dependent areas distal to a chronic coronary artery occlusion were studied in chronically instrumented, conscious dogs. Nisoldipine produced significant and dose-related decreases in arterial blood pressure, an elevation of heart rate and large increases in coronary blood flow velocity. In dogs with an Ameroid constrictor previously implanted to enhance coronary collateral development, this agent produced large increases in perfusion distal to a chronic coronary artery occlusion. In addition, despite a reduction in arterial pressure, nisoldipine preserved renal cortical, intestinal and skeletal muscle blood flow while increasing tissue flow within liver and cerebral cortex. Thus, nisoldipine increases oxygen supply to collateral-dependent myocardium in the presence of reduced driving pressure for collateral perfusion. |
| Databáze: | OpenAIRE |
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