Secretory Sorcery: Paneth Cell Control of Intestinal Repair and HomeostasisSummary

Autor: Paul Cray, Christopher M. Dekaney, Breanna Sheahan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Review
RC799-869
cADPR
cyclic ADP-ribose
medicine.disease_cause
UPR
unfolded protein response
Crohn Disease
Homeostasis
Intestinal Mucosa
PC
Paneth cell
ATG16L1
TNF
tumor necrosis factor
Mutation
DLL
delta like ligand
Microbiota
Stem Cells
Gastroenterology
Cell Differentiation
Diseases of the digestive system. Gastroenterology
GI
gastrointestinal
HD5
human defensin5
Cell biology
medicine.anatomical_structure
Cellular Microenvironment
ATG16L1
autophagy related 16 like 1
LPS
lipopolysaccharide
Disease Susceptibility
Stem cell
ER stress
damage
Signal Transduction
aISC
active intestinal stem cell
mTOR
mammalian target of rapamycin
Biology
digestive system
ER
endoplasmic reticulum
SI
small intestine
medicine
Animals
Humans
Regeneration
intestine
EGF
epidermal growth factor
Wound Healing
NEC
necrotizing enterocolitis
KO
knockout
Innate immune system
Host Microbial Interactions
Hepatology
SCF
stem cell factor
reversion
Autophagy
GVHD
graft-vs-host disease
Paneth cells
IR
irradiation
IL
interleukin
Paneth cell
Unfolded protein response
FZD5
Frizzled5
HD6
human defensin6
MMP7
matrix metalloproteinase-7
DXR
doxorubicin
MAPK
mitogen-activated protein kinase
Zdroj: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1239-1250 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Popis: Paneth cells are professional secretory cells that, classically, play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria. In this role, Paneth cells are able to sense ques from luminal bacteria and respond by changing production of these factors to protect the epithelial barrier. Paneth cells rely on autophagy to regulate their secretory capability and capacity. Disruption of this pathway through mutation of genes, such as Atg16L1, results in decreased Paneth cell function, dysregulated enteric microbiota, decreased barrier integrity, and increased risk of diseases such as Crohn’s Disease in humans. Upon differentiation Paneth cells migrate downward and intercalate among active intestinal stem cells at the base of small intestinal crypts. This localization puts them in a unique position to interact with active intestinal stem cells, and recent work shows that Paneth cells play a critical role in influencing the intestinal stem cell niche. This review discusses the numerous ways Paneth cells can influence intestinal stem cells and their niche. We also highlight the ways in which Paneth cells can alter cells and other organ systems.
Databáze: OpenAIRE
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