Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma
| Autor: | Man‑Man Liu, Lian Zhou, Ji‑Zhi Zhao, Mu Wang, Chao Ma, Li‑Jiang Yu, Run‑Tai Lin, Tao Zhang, Yong‑Ning Chen, Tian‑Yin Shi, Yao‑Ran Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Cluster of differentiation biology Oncogene business.industry Cadherin CD44 Cancer Articles medicine.disease Molecular medicine Metastasis 03 medical and health sciences stomatognathic diseases 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology Cervical lymph nodes 030220 oncology & carcinogenesis medicine Cancer research biology.protein business |
| Popis: | Oral squamous cell carcinoma (OSCC) is a highly invasive lesion that frequently metastasizes to the cervical lymph nodes and is associated with a poor prognosis. Several adhesion factors, including cadherin 6 (CDH6), cadherin 11 (CDH11) and cluster of differentiation 44 (CD44), have been reported to be involved in the invasion and metastasis of multiple types of cancer. Therefore, the aim of the present study was to determine the expression of CDH6, CDH11 and CD44 in tumor tissues from patients with OSCC, and whether this was associated with the metastasis and survival of OSCC. The mRNA expression of the human tumor metastasis-related cytokines was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in OSCC tumors with or without lymph node metastasis (n=10/group). The expression of CDH6, CDH11 and CD44 in 101 OSCC and 10 normal oral mucosa samples was examined by immunohistochemical staining. The association between overall and disease-specific survival times of patients with OSCC and the expression of these three proteins was evaluated using Kaplan-Meier curves and the log-rank test. RT-qPCR results indicated that the mRNA expression of CDH6, CDH11 and CD44 was increased in OSCC patients with lymph node metastasis (2.93-, 2.01- and 1.92-fold; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|