Discovery of novel sulfonated small molecules that inhibit vascular tube formation
| Autor: | Umesh R. Desai, Balagurunathan Kuberan, Karthik Raman, Rajesh Karuturi, Vimal P. Swarup |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Angiogenesis
Clinical Biochemistry Drug Evaluation Preclinical Oligosaccharides Pharmaceutical Science Angiogenesis Inhibitors Microtubules Biochemistry Article Small Molecule Libraries Biomimetic Materials Drug Discovery Animals Receptor Molecular Biology Tube formation chemistry.chemical_classification Matrigel Chemistry Organic Chemistry Endothelial Cells Oligosaccharide Small molecule In vitro Molecular Medicine Cattle Sulfur |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:4467-4470 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2012.04.014 |
| Popis: | Tumor-associated angiogenesis is a complex process that involves the interplay among several molecular players such as cell-surface heparan sulfate proteoglycans, vascular endothelial growth factors and their cognate receptors. PI-88, a highly sulfonated oligosaccharide, has been shown to have potent anti-angiogenic activity and is currently in clinical trials. However, one of the major drawbacks of large oligosaccharides such as PI-88 is that their synthesis often requires numerous complex synthetic steps. In this study, several novel polysulfonated small molecule carbohydrate mimetics, which can easily be synthesized in fewer steps, are identified as promising inhibitors of angiogenesis in an in vitro tube formation assay. |
| Databáze: | OpenAIRE |
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