A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly({\epsilon}-caprolactone) dimethacrylate co-network by scalable free surface electrospinning
| Autor: | Giuseppe Tronci, Mohamed Basel Bazbouz, He Liang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Materials science Vinyl Compounds Surface Properties Ultraviolet Rays Polyesters Sus scrofa Nanofibers Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Gelatin Biomaterials Contact angle food Differential scanning calorimetry Cell Line Tumor Physics - Chemical Physics Benzyl Compounds Spectroscopy Fourier Transform Infrared Animals Humans Surface Tension Aqueous solution Calorimetry Differential Scanning Viscosity Electric Conductivity Temperature technology industry and agriculture Water Membranes Artificial Physics - Applied Physics 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences Solutions Membrane Chemical engineering Mechanics of Materials Attenuated total reflection Wettability Methacrylates Wetting 0210 nano-technology |
| Popis: | Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. Crosslinking of electrospun fibres from gelatin is required to prevent dissolution in water, to retain the original nanofibre morphology after immersion in water, and to improve the thermal and mechanical properties, although this is still challenging to accomplish in a controlled fashion. In this study, we have investigated the scalable manufacture and structural stability in aqueous environment of a UV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES) of aqueous solutions containing vinylbenzylated gelatin and poly(epsilon-caprolactone) dimethacrylate (PCL-DMA). Vinylbenzylated gelatin was obtained via chemical functionalisation with photopolymerisable 4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase in electrospun fibres were integrated in a covalent UV-cured co-network at the molecular scale, rather than being simply physically mixed. UV-cured nanofibrous membranes did not dissolve in water and showed enhanced thermal and mechanical properties, with respect to as-spun samples, indicating the effectiveness of the photo-crosslinking reaction. In addition, UV-cured gelatin/PCL membranes displayed increased structural stability in water with respect to PCL-free samples and were highly tolerated by G292 osteosarcoma cells. These results therefore support the use of PCL DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water insoluble, mechanical competent gelatin membranes for healthcare applications. Comment: 11 Figures, 1 Table, to appear in Materials Science and Engineering C |
| Databáze: | OpenAIRE |
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