Ontogeny of enhancing factor in mouse intestines and skin
| Autor: | S. J. Desal, Deo Mg, A. S. Wagle, R. Mulherkar |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Histology Ratón Ontogeny Biology Group II Phospholipases A2 Antibodies Phospholipases A Immunoenzyme Techniques Mice Hair cycle Epidermal growth factor Internal medicine Intestine Small medicine Animals Intestinal Mucosa Molecular Biology Chromatography High Pressure Liquid Skin Mice Inbred BALB C Staining and Labeling Cell Biology General Medicine Cell biology Medical Laboratory Technology medicine.anatomical_structure Endocrinology Paneth cell Immunohistochemistry Anatomy General Agricultural and Biological Sciences Peptides A431 cells Developmental biology Hair |
| Zdroj: | Histochemistry. 96(4) |
| ISSN: | 0301-5564 |
| Popis: | Enhancing Factor (EF) is a 14 kDa protein isolated from mouse small intestines, which enhances the binding of 125I-EGF to A431 cells. This observation as well as our earlier in vitro studies have indicated that EF is a modulator of EGF. In adult mice, localization of EF by immunohistochemistry shows it is present pre-dominantly in the Paneth cells of the small intestines and to a lesser extent in the stomach and colon. This study of the ontogeny of EF shows that the appearance of the protein coincides with the appearance of mature Paneth cells. In new born mouse skin EF is localized in the hair follicles in the first hair cycle from day 2 to day 8. It is however absent in the adult skin. Thus EF is associated with tissues which have a high growth rate. |
| Databáze: | OpenAIRE |
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