Determination of the brominated flame retardant, hexabromocyclododecane, in sediments and biota by liquid chromatography-electrospray ionisation mass spectrometry

Autor: Bart N. Zegers, C.R. Allchin, Jan P. Boon, Philippe Bersuder, J. de Boer, P.E.G. Leonards, Steven Morris
Přispěvatelé: Chemistry and Biology, Institute for Environmental Studies
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Zdroj: TrAC : Trends in Analytical Chemistry, 25(4), 343-349
Morris, S, Bersuder, P, Allchin, C R, Zegers, B, Boon, J P, Leonards, P E G & de Boer, J 2006, ' Determination of the brominated flame retardant, hexabromocyclododecane, in sediments and biota by liquid chromatography-electrospray ionisation mass spectrometry ', TrAC. Trends in Analytical Chemistry, vol. 25, no. 4, pp. 343-349 . https://doi.org/10.1016/j.trac.2005.11.006
TrAC : Trends in Analytical Chemistry 25 (2006) 4
TrAC. Trends in Analytical Chemistry, 25(4), 343-349. Elsevier
ISSN: 0165-9936
DOI: 10.1016/j.trac.2005.11.006
Popis: A method involving reversed-phase, liquid chromatography coupled to electrospray ionisation mass spectrometry (LC-ESI-MS) was developed for separation, detection and quantitation of the alpha-, beta- and gamma-diastereoisomers of hexabromocyclododecane (HBCD). To address the lack of environmental data of this high-production-volume chemical, and to begin to understand the behaviour, the fate and the effects of these stereoisomers, a diastereoisomer-specific method is necessary. Currently, HBCD stereomeric separation is not possible using gas chromatography; thermally-induced rearrangements as well as decomposition of the compound occur at temperatures > 240 degrees C by the initial elimination of hydrogen bromide. The extraction of HBCDs, and subsequent clean-up procedures are similar to those used for polybrominated diphenylethers, and include Soxhlet, homogenisation, mechanical shaking, sulphuric acid treatment and gel-permeation chromatography. Single-quadrupole and ion-trap mass analysers as well as LC separations were optimised using pure and individual HBCD stereoisomers, and determinations were performed using selected ion monitoring (m/z 640.7) of the [M-H](-) ion. This article presents options for analyte extraction and information regarding instrument optimisation, and demonstrates that LC-MS is a suitable technique for quantifying HBCD stereoisomers in complex environmental matrices.
Databáze: OpenAIRE
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