Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry
| Autor: | Shuang Ci, Alec Okun, Nathan Eyde, Michael H. Ossipov, Jennifer Y. Xie, Frank Porreca, Howard L. Fields, Tamara King, Edita Navratilova, Chaoling Qu |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Models Neurological Pain Nucleus accumbens Nucleus Accumbens Midbrain Rats Sprague-Dawley Limbic system Reward Dopamine Dopaminergic Cell medicine Limbic System Animals Anesthetics Local Afferent Pathways Pain Postoperative Multidisciplinary Dopaminergic Ventral Tegmental Area Nerve Block Biological Sciences Conditioned place preference Rats Ventral tegmental area Disease Models Animal medicine.anatomical_structure Dopamine Antagonists Psychology Neuroscience Reinforcement Psychology medicine.drug |
| Popis: | Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry. |
| Databáze: | OpenAIRE |
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