Risk of Nephrolithiasis and Nephrocalcinosis in Patients with Chronic Hypoparathyroidism:A Retrospective Cohort Study
| Autor: | Fan Mu, Joshua A Young, James Signorovitch, Kristina Chen, Lars Rejnmark, Markus Ketteler, Nicole Sherry, Elvira O. Gosmanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Active vitamin Hypoparathyroidism Kidney stones Parathyroid hormone Nephrolithiasis Kidney Calculi Internal medicine Chronic kidney disease medicine Active vitamin D Humans Pharmacology (medical) Original Research Retrospective Studies business.industry Hypoparathyroidism/complications Hazard ratio Retrospective cohort study Nephrocalcinosis/complications General Medicine medicine.disease Rheumatology Nephrocalcinosis Calcium Diagnosis code business Tomography X-Ray Computed Chronic hypoparathyroidism |
| Zdroj: | Ketteler, M, Chen, K, Gosmanova, E O, Signorovitch, J, Mu, F, Young, J A, Sherry, N & Rejnmark, L 2021, ' Risk of Nephrolithiasis and Nephrocalcinosis in Patients with Chronic Hypoparathyroidism : A Retrospective Cohort Study ', Advances in Therapy, vol. 38, no. 4, pp. 1946-1957 . https://doi.org/10.1007/s12325-021-01649-2 Advances in Therapy |
| Popis: | Introduction Chronic hypoparathyroidism managed with conventional treatment, comprising oral administration of calcium and active vitamin D, has been associated with renal complications, including nephrolithiasis and nephrocalcinosis. Further larger-scale studies are needed to examine these risks. This study evaluated the risk of nephrolithiasis and nephrocalcinosis in patients with chronic hypoparathyroidism. Methods A retrospective cohort study using a managed care claims database in the United States from January 2007 to June 2017. Included patients were those with chronic hypoparathyroidism (excluding those receiving parathyroid hormone) and randomly selected patients without hypoparathyroidism over a maximum of 5-year follow-up. The main outcome measures were nephrolithiasis, identified by diagnosis codes or procedure codes for removing kidney stones, and nephrocalcinosis, identified by diagnosis codes. Results The nephrolithiasis analyses included 8097 adult patients with hypoparathyroidism and 40,485 adult patients without hypoparathyroidism. After excluding patients with a diagnosis of nephrocalcinosis at baseline, nephrocalcinosis analyses included 8051 patients with hypoparathyroidism and 40,466 patients without hypoparathyroidism. During 5 years of follow-up, patients with chronic hypoparathyroidism had significantly increased risk of nephrolithiasis and nephrocalcinosis in Kaplan–Meier analysis compared with patients without hypoparathyroidism (both P |
| Databáze: | OpenAIRE |
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