Pretreatment maximum standardized uptake value in 18F-fluorodeoxyglucose positron emission tomography-computed tomography as a prognostic factor for ovarian clear cell carcinoma and low-grade serous carcinoma

Autor: Ryoko Asano, Toshihiro O'uchi, Eri O'uchi, Naoyuki Miyasaka, Takuto Matsuura, Isao Otsuka
Rok vydání: 2021
Předmět:
Adult
Prognostic factor
medicine.medical_specialty
Positron emission tomography-computed tomography
Serous carcinoma
Standardized uptake value
lcsh:Gynecology and obstetrics
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Predictive Value of Tests
Reference Values
Positron Emission Tomography Computed Tomography
Internal medicine
Carcinoma
Humans
Medicine
Mucinous carcinoma
Epithelial ovarian cancer
Positron emission
lcsh:RG1-991
Aged
Neoplasm Staging
Retrospective Studies
Aged
80 and over
Ovarian Neoplasms
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Middle Aged
Reference Standards
Prognosis
medicine.disease
Cystadenocarcinoma
Serous
Survival Rate
Clear cell carcinoma
Female
Radiopharmaceuticals
business
Adenocarcinoma
Clear Cell
Zdroj: Taiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 2, Pp 305-310 (2021)
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2021.01.009
Popis: Objective The maximum standardized uptake value (SUVmax) derived by positron emission tomography-computed tomography (PET/CT) can be an index of biological tumor aggressiveness, which is assessed using noninvasive tools before the treatment of epithelial ovarian cancer (EOC). This study aimed to evaluate the prognostic value of the pretreatment SUVmax in patients with EOC. Materials and methods We reviewed the data of patients with EOC who underwent pretreatment 18F-FDG PET/CT between June 2006 and September 2016. The relationships between pretreatment SUVmax and histological subtypes of EOC were determined. Moreover, progression-free survival (PFS) and overall survival (OS) were evaluated according to the pretreatment SUVmax. Risk factors associated with progression or death were also analyzed. Results Of 148 patients, 66 (44.6%), 11 (7.4%), 34 (23.0%), 19 (12.8%), 15 (10.1%), and three (2.0%) were diagnosed with high-grade serous carcinoma (HGSC), low-grade serous carcinoma (LGSC), clear cell carcinoma (CCC), endometrioid carcinoma, mucinous carcinoma, and others, respectively. The median SUVmax was marginally lower in LGSC (6.80 vs. 10.5; P = 0.059) and significantly lower in CCC (5.92 vs. 10.5; P = 0.001) than in HGSC. A high pretreatment SUVmax (≥9.30) was a prognostic factor for OS in patients with LGSC (P = 0.046). Furthermore, multivariate analysis revealed that a high SUVmax (≥5.85) was an independent prognostic factor for OS (P = 0.046) in patients with CCC. However, a high SUVmax (≥7.77) was a poor predictor of PFS and OS in patients with EOC (P = 0.156 and P = 0.158, respectively). Conclusion Our findings suggest that the pretreatment SUVmax is not only an independent predictor of survival in patients with CCC but also a significant predictor of survival in patients with LGSC.
Databáze: OpenAIRE
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