Revised diagnostic criteria for neuromyelitis optica (NMO) - Application in a series of suspected patients
Autor: | Francesc Graus, Bruno Tavolato, Bruno Giometto, Albert Saiz, Yolanda Blanco, Luigi Zuliani |
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Přispěvatelé: | Saiz, A, Zuliani, L, Blanco, Y, Tavolato, B, Giometto, B, Graus, F |
Rok vydání: | 2007 |
Předmět: |
Adult
Male medicine.medical_specialty Pathology Multiple Sclerosis Optic Neuritis Gastroenterology Transverse myelitis Central nervous system disease Cohort Studies Diagnosis Differential Predictive Value of Tests Recurrence Internal medicine Medicine Humans Optic neuritis Age of Onset Neuroradiology Aged Autoantibodies Aquaporin 4 Neuromyelitis optica business.industry Multiple sclerosis Neuromyelitis Optica Middle Aged medicine.disease Neurology Predictive value of tests Immunoglobulin G Female Neurology (clinical) Age of onset business Biomarkers |
Popis: | We analyzed neuromyelitis optica (NMO) IgG in the serum or CSF samples from 46 patients with suspected NMO (28) and limited forms of NMO (18). One hundred and fifteen samples from multiple sclerosis (MS) patients were included as controls. The final clinical diagnosis after follow-up was 16 NMO, 12 MS, 11 transverse myelitis (TM) and seven recurrent optic neuritis (RON). NMO-IgG was detected in 62.5% of NMO, 50% of the recurrent longitudinally extensive TM, 14.3% of the RON but in none of the MS patients. The authors then compared the newly revised diagnostic criteria for NMO with the criteria published in 1999, in the 28 patients with suspected NMO. The revised criteria had higher specificity, and positive and negative predictive value (83.3% vs. 25%; 87.5% vs. 62.5; 83.3% vs. 75%), but slightly lower sensitivity (87.5% vs. 93.7%). Our study confirms NMO-IgG as a highly specific marker of NMO, and the usefulness of the revised diagnostic criteria in predicting a diagnosis of NMO. |
Databáze: | OpenAIRE |
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