Acute effects of diesel emission from the urea selective catalytic reduction engine system on male rats

Autor:	Tsuyoshi Ito, Toru Nakajima, Naomi Tsukue, Gen Sugiyama, Atsunaka Kato
Rok vydání:	2010
Předmět:	Male Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Nitrogen Dioxide Air Pollutants Occupational Weight Gain Toxicology Diesel engine Catalysis chemistry.chemical_compound Diesel fuel Oxidants Photochemical Air Pollution medicine Animals Urea Nitrogen dioxide RNA Messenger Lung Oligonucleotide Array Sequence Analysis Vehicle Emissions Inhalation Sulfhydryl Reagents Deoxyguanosine Selective catalytic reduction Organ Size Particulates Rats Inbred F344 Rats Trachea Dithiothreitol Oxidative Stress chemistry 8-Hydroxy-2'-Deoxyguanosine Particulate Matter Bronchoalveolar Lavage Fluid Nuclear chemistry
Zdroj:	Inhalation Toxicology. 22:309-320
ISSN:	1091-7691 0895-8378
DOI:	10.3109/08958370903307652
Popis:	Short-term inhalation experiments were performed using Fischer 344 rats exposed to emission from the urea selective catalytic reduction (SCR) diesel engine system to identify health effects and compare them to those of the conventional diesel engine system. Rats were exposed to high-, middle-, or low-concentration emission (dilution ratio 1:29, 1:290, or 1:580) or clean air (control) for 1, 3, or 7 days (6 h/day), under driving conditions at a speed of 1320 rpm and a torque of 840 Nm. For the high-concentration group, the major components of the urea SCR emission were 0.04 mg/m(3) particulate matter (PM) and 0.78 ppm nitrogen dioxide (NO(2)); those of the conventional emission were 0.95 mg/m(3) PM and 0.31 ppm NO(2). The authors evaluated the respiratory effects of each emission on rats. Lymphocytes for 3-day exposure of both emissions significantly increased in bronchoalveolar lavage fluid, but there were slight differences. With an increase in potential antioxidant (PAO), 8-hydroxy-2'-deoxyguanosine for the urea SCR emission was significantly decreased, but that of the conventional emission was highest among all groups and did not show a response to PAO. In lungs, heme oxygenase (HO)-1 and tumor necrosis factor (TNF)-alpha mRNA expressions for the urea SCR emission showed a tendency to increase compared to those of the conventional emission. Thus, gene analysis results suggested that NO(2) from the urea SCR emission affected the expressions of mRNAs in lungs. However, as a whole, the results suggested that the health effects of the urea SCR emission might be less than the conventional emission on rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651daba8eaf89f07adfca30de013c184 https://doi.org/10.3109/08958370903307652 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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